Ty-jour t1 - 汽油诱导的血液神学变化和白化大鼠y1 - 2009-01-31 N2 - 血液学和生化指标的相关肝毒性用于监测汽油在白化大鼠汽油的毒性。大鼠置于四组和分别腹膜内施用0.0,2.0,4.0和10.0g / kg汽油，2个期为1和2个月。在每个时期结束时，将大鼠从每组中取出进行分析。用生理盐水类似地处理对照大鼠。采用血红蛋白（HB），包装细胞体积（PCV）和白细胞计数（WBC）进行血液样品。血清酶如天冬氨酸转氨酶（AST），丙氨酸转氨酶（ALT），碱性磷酸酶（ALP）。同等监测谷胱甘肽-S-转移酶（GST）和谷胱甘肽（GSH）。Hb和PCV的显着降低，特别是在第四组大鼠中收到的。10gkg-1gasoline与对照和其他相比（P <0.05）。记录了第一个月的白细胞数量对汽油暴露于汽油的显着降低，特别是在给予10gkg-1gasoline的大鼠中。 Substantial increase in the activities of liver enzymes - ALT, AST and ALP were observed in all the groups. However, GST increased marginally from first to second month in all the groups. Furthermore, there was consistent reduction in the level of GSH after the first dose in all the groups compared with control (P < 0.05). The study demonstrates that long term exposure of rats to gasoline could induce anaemia and liver damage. JF - Current World Environment JA - VL - 10 IS - 11 UR - www.a-i-l-s-a.com/article/157/ SP - EP - PB - M3 - 10.12944/CWE.4.1.07 ER -